Course of virologic breakthroughs under long-term lamivudine in HBeAg-negative precore mutant HBV liver disease
نویسندگان
چکیده
منابع مشابه
long-term efficacy of treatment with lamivudine in hbeag-negative patients with decompensated cirrhosis due to chronic hepatitis b
background: the prognosis of patients with decompensated cirrhosis due to hepatitis b is very poor. it has been shown that lamivudine can improve liver function and delay the need for liver transplantation in hbeag-positive patients with decompensated cirrhosis. however, information regarding long-term use of lamivudine in hbeag-negative patients with cirrhosis is limited. the primary objective...
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The optimal duration of oral nucleos(t)ide analogue therapy for HBeAg negative chronic hepatitis B (CHB) has not been defined. The aim of this study was to investigate the clinical efficacy of 24-months course of lamivudine therapy in patients with HBeAg negative CHB in Korea. A total of 50 Korean patients with HBeAg negative CHB were prospectively enrolled. The patients received 100 mg/day of ...
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BACKGROUND Hepatitis B virus (HBV) infection is an important health concern worldwide, with critical outcomes. Hepatitis B e antigen (HBeAg) negative chronic hepatitis B is frequently caused by a mutation (G1896A) in the hepatitis B virus (HBV) precore (PC) reading frame, which creates a stop codon, causing premature termination of the HBe protein. OBJECTIVES This study aimed to investigate t...
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متن کاملHBV DNA suppression and HBsAg clearance in HBeAg negative chronic hepatitis B patients on lamivudine therapy for over 5 years.
BACKGROUND & AIMS In long-term responder patients, it is unclear whether lamivudine (LAM) monotherapy should be continued or switched to a high-genetic-barrier analogue. This study aims at assessing LAM efficacy over a 5-year period and the residual risk of drug resistance. The rate of HBsAg clearance and LAM long-term safety profile were also evaluated. METHODS One hundred and ninety-one pat...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2002
ISSN: 0270-9139
DOI: 10.1053/jhep.2002.33894